Royal College Press Office: Do they read or understand their own papers?

There's a retrospective study in this month's issue of The Psychiatrist titled: "Use of anti-dementia drugs and delayed care home placement: an observational study". It's not the best study in the world but the authors appropriately acknowledge the limitations, explicitly stating in the abstract that: "However, based on purely observational data, no conclusion can be made as to whether such association is causal."

It was a retrospective study which means that it couldn't compensate for all sorts of factors that may have confounded the finding that, "...there was a delay in care home placement by a median of 12 months in those who took ChEIs compared with those who did not." This is not the first study to suggest that anti-dementia drugs may delay admission to care homes, and many other studies were much better designed and prospective. Importantly, the authors state: "...at the end of the follow-up there was no significant reduction in the probability of being in a care home setting between those who had taken ChEIs compared with those who had not." So, the drugs didn't prevent care home admission, only that those that took drugs were admitted to care homes later than those that didn't. The authors mention that the groups weren't matched and only suggest that there weren't differences. However, no comparisons are reported and the authors don't provide detail on the factors that they themselves report as potential confounders.

It's not possible to know, for example, if those that took anti-dementia drugs were of a less-advanced stage or if they had less comorbidity - neither of these things appear to have been corrected for. This means that more unwell patients might have been considered unsuitable for the drugs and their course of illness would mean that they were already closer to admission. Since the two groups (receiving drug and control) weren't described in detail (in terms of age, diagnosis, severity of illness, medical illness) we can't be sure if the drugs had anything to do with it.

You might hope that such limitations would be taken into account. But the RCPsych press office announce that:

Anti-dementia drugs may help delay people’s admission to care homes

This is precisely what the study didn't say and what the authors were careful to caution against concluding. Still, it seems that the scientific credibility of the RCPsych is less important than getting 'good news' headlines.